| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1542 | |
| Phytochemical name or plant extracts | (-)-maackiain | |
| PMID | 31487934 | |
| Literature evidence | In this study, four novel isoflavanes (1-3 and 5) and four known analogues (4 and 6-8) were isolated from an ethanolic extract of the rattans of S. suberectus. | |
| IUPAC name | (1R,12R)-5,7,11,19-tetraoxapentacyclo[10.8.0.02,10.04,8.013,18]icosa-2,4(8),9,13(18),14,16-hexaen-16-ol | |
| Phytochemicals’ class or type of plant extracts | Isoflavonoid | |
| Source of phytochemicals or plant Extracts | Spatholobus suberectus | |
| Geographical availability | Assam, China South-Central, China Southeast, East Himalaya, Laos, Thailand, Vietnam | |
| Plant parts | Raatan | |
| Other cancers | Breast cancer, Oral cancer, Pancreatic cancer, Lung cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | >100 µM against MCF-7 25.1 ± 7.7 µM against MDA-MB-231 | |
| Potency | Interestingly, compounds 1 and 2 only inhibited the proliferation of MCF-7 cells, while compound 6 showed a selective cytotoxicity against MDA-MB-231 cells. Compound 6 is Maackiain | |
| Cell line/ mice model | MDA-MB-231, MCF-7, Hep3B, H1299, HeLa, MCF-7, BHY, Miapaca‑2, Colo‑205, A-549 | |
| Additional information | NA | |
| PubChem ID | 91510 | |
| Additional PMIDs | 31963799 25434991 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:519185-1 | |
| Safety | NA |