| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1211 | |
| Phytochemical name or plant extracts | (-)-Xanthatin | |
| PMID | 23824011 | |
| Literature evidence | Since the anti-cancer drug etoposide, a selective Topo II? inhibitor, has also been shown to induce intracellular ROS, (-)-xanthatin may exert its anti-proliferative effects on cancer cells in a similar manner to those of etoposide. | |
| IUPAC name | (3aR,7S,8aS)-7-methyl-3-methylidene-6-[(E)-3-oxobut-1-enyl]-4,7,8,8a-tetrahydro-3aH-cyclohepta[b]furan-2-one | |
| Phytochemicals’ class or type of plant extracts | Sesquiterpene lactone | |
| Source of phytochemicals or plant Extracts | Xanthium strumarium | |
| Geographical availability | Afghanistan, Albania, Algeria, Bulgaria, Cambodia, China North-Central, China South-Central, China Southeast, Corse, Czechoslovakia, East Aegean Is., East European Russia, East Himalaya, France, Greece, Hainan, Hungary, India, Inner Mongolia, Iran, Italy, Kriti, Krym, Laos, Lebanon-Syria, Manchuria, Mongolia, Morocco, Myanmar, North Caucasus, Pakistan, Palestine, Portugal, Qinghai, Romania, Sardegna, Sicilia, Sinai, South European Russi, Spain, Sri Lanka, Switzerland, Tadzhikistan, Taiwan, Thailand, Tibet, Transcaucasus, Turkey, Turkey-in-Europe, Turkmenistan, Ukraine, Uzbekistan, West Himalaya, Xinjiang, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Lung cancer, Colon cancer | |
| Target gene or protein | GADD45γ, c-fos | |
| Gene or Protein evidence | (-)-Xanthatin in particular exhibited stronger anti-proliferative potential than that of etoposide, which underlies the marked induction of c-fos/GADD45γ and ROS production. | |
| Target pathways | GADD45γ-primed JNK and p38 signaling pathways | |
| IC50 | 5.28 µM against MDA-MB-231 fo 48h. | |
| Potency | We reported that (–)-xanthatin, a xanthanolide sesquiterpene lactone present in the Cocklebur plant, exhibited potent anti-proliferative effects on human breast cancer cells | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | It is noteworthy that (–)-xanthatin in particular exhibited much stronger anti-proliferative potential than that of etoposide, underlying marked c-fos/GADD45γ induction and ROS production in vitro. | |
| PubChem ID | 5281511 | |
| Additional PMIDs | 18066118 21568272 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:260893-1 | |
| Safety | NA |