| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1678 | |
| Phytochemical name or plant extracts | (-)-Oleocanthal (OC) | |
| PMID | 30781364 | |
| Literature evidence | This study reveals the OC future potential as combination therapy to sensitize HER2-overexpressing breast cancers and significantly reduce required doses of targeted HER family therapeutics. | |
| IUPAC name | 2-(4-hydroxyphenyl)ethyl (E,3S)-4-formyl-3-(2-oxoethyl)hex-4-enoate | |
| Phytochemicals’ class or type of plant extracts | Phenolic secoiridoid | |
| Source of phytochemicals or plant Extracts | Olea europaea | |
| Geographical availability | Afghanistan, Albania, Algeria, Angola, Baleares, Botswana, Burundi, Canary Is., Cape Provinces, China South-Central, Cyprus, Djibouti, East Aegean Is., Eritrea, Ethiopia, Free State, Greece, Iran, Italy, Kenya, Kriti, KwaZulu-Natal, Lesotho, Libya, Madeira, Malawi, Mauritius, Morocco, Mozambique, Namibia, Nepal, Niger, Northern Provinces, Oman, Pakistan, Palestine, Portugal, Rwanda, Réunion, Sardegna, Saudi Arabia, Sicilia, Somalia, Spain, Sudan, Swaziland, Tanzania, Tunisia, Turkey, Turkey-in-Europe, Uganda, West Himalaya, Yemen, Yugoslavia, Zambia, Zaïre, Zimbabwe | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | EGFR | |
| Gene or Protein evidence | Activated c-Met, EGFR, HER2, and protein kinase B (AKT) were significantly suppressed in combination-treated mice tumors, compared to OC or LP monotherapy. | |
| Target pathways | Moreover, (-)-oleocanthal treatment effects were found to be mediated via inhibition of HGF-induced c-Met activation and its downstream mitogenic signaling pathways. | |
| IC50 | NA | |
| Potency | This study reveals the OC future potential as combination therapy to sensitize HER2-overexpressing breast cancers and significantly reduce required doses of targeted HER family therapeutics. | |
| Cell line/ mice model | BT-474 and SKBR-3 | |
| Additional information | Olive oil rich in various bioactive compounds like oleanolic acid, oleuropein, oleocanthal, and hydroxytyrosol is known for its anti-inflammatory as well as cardioprotective property. | |
| PubChem ID | 11652416 | |
| Additional PMIDs | 33845735 21328179 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:610675-1 | |
| Safety | NA |