| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1794 | |
| Phytochemical name or plant extracts | (-)-Gossypol-enriched cottonseed oil [(-)-GPCSO] | |
| PMID | 23482766 | |
| Literature evidence | Previous studies have demonstrated that both (-)-gossypol and (-)-GPCSO have potent anticancer activity against multiple types of cancer, including breast cancer. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Cottonseed oil | |
| Source of phytochemicals or plant Extracts | Gossypium herbaceum | |
| Geographical availability | Afghanistan, Angola, Botswana, Caprivi Strip, Iran, Iraq, KwaZulu-Natal, Lebanon-Syria, Mozambique, Namibia, Northern Provinces, Swaziland, Zimbabwe | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-2 | |
| Gene or Protein evidence | (-)-gossypol-enriched cottonseed oil [(-)-GPCSO] can down-regulate Bcl-2 expression in MCF-7 and primary cultured human breast cancer epithelial cells (PCHBCECs). | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | (−)-GPCSO at 500 and 1000 μg/ml reduced the number of pre-adipocytes by 41% and 60% (p<0.05), respectively, when compared to control cells. | |
| Cell line/ mice model | MDA-MB-231, MCF-7 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | 21710341 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:559730-1 | |
| Safety | NA |