| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-619 | |
| Phytochemical name or plant extracts | (-)-Acuminatin | |
| PMID | 15256759 | |
| Literature evidence | In DNA topoisomerase I and II assays in vitro at a concentration of 100 microM, 4 showed the most potent inhibitory activity, 93.6 and 82.1% inhibition, respectively, and 8 showed 79.1 and 34.3% inhibition, respectively. | |
| IUPAC name | (2S,3S)-2-(3,4-dimethoxyphenyl)-7-methoxy-3-methyl-5-[(E)-prop-1-enyl]-2,3-dihydro-1-benzofuran | |
| Phytochemicals’ class or type of plant extracts | Lignan | |
| Source of phytochemicals or plant Extracts | Machilus thunbergii | |
| Geographical availability | China North-Central, China Southeast, Japan, Korea, Nansei-shoto, Taiwan, Vietnam | |
| Plant parts | Bark | |
| Other cancers | Breast cancer, Colon cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 84.6 µM against MCF-7 | |
| Potency | These results suggest that (-)-acuminatin, (-)-isoguaiacin and meso-dihydroguaiaretic acid exert diverse hepatoprotective activities, perhaps by serving as potent antioxidants. | |
| Cell line/ mice model | MCF-7, HT-29 | |
| Additional information | NA | |
| PubChem ID | 6442251 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:466273-1 | |
| Safety | NA |