| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1947 | |
| Phytochemical name or plant extracts | (+)-pinoresinol di-O-β-d-allopyranoside | |
| PMID | 29734650 | |
| Literature evidence | This study was designed to search for novel anti-cancer compounds from natural plants. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Lignan | |
| Source of phytochemicals or plant Extracts | Cimicifuga dahurica | |
| Geographical availability | Amur, China North-Central, China Southeast, Chita, Inner Mongolia, Khabarovsk, Korea, Manchuria, Mongolia, Primorye | |
| Plant parts | Rhizome | |
| Other cancers | Breast cancer | |
| Target gene or protein | c-Myc, Cyclin D1, Bcl-2 | |
| Gene or Protein evidence | Western blot protein expression analysis showed a down expression of c-Myc and cyclin D1 which further elucidated the anti-proliferation mechanism of compound 7 while apoptotic effects were found in association with Bcl-2 family protein expression variations. Compound 7 is (+)-pinoresinol di-O-β-d-allopyranoside | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Wherein compound 7 showed the most significant anti-proliferative and cell cycle arresting effect (p ≤ 0.05) which followed a dose dependent manner. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Conclusively this study reports the isolation and identification of 17 compounds from C. dahurica, including four novel molecules, in addition to the fact that compound 7 possesses significant anti-proliferative and apoptotic effects in vitro that may require further exploration. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:709429-1 | |
| Safety | NA |