| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1103 | |
| Phytochemical name or plant extracts | (+)-pinoresinol | |
| PMID | 18656934 | |
| Literature evidence | Dihydroconiferyl alcohol, (+)-lariciresinol, (+)-pinoresinol, (+)-syringaresinol, and protocatechuic acid methyl ester exhibited cytoprotective activity in cultured MCF-7 cells stressed by H2O2. | |
| IUPAC name | 4-[(3S,3aR,6S,6aR)-6-(4-hydroxy-3-methoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxyphenol | |
| Phytochemicals’ class or type of plant extracts | Lignan | |
| Source of phytochemicals or plant Extracts | Euterpe oleracea | |
| Geographical availability | Brazil North, Brazil Northeast, Colombia, Ecuador, French Guiana, Guyana, Suriname, Trinidad-Tobago, Venezuela | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer, Colon cancer, Prostate cancer | |
| Target gene or protein | p53 | |
| Gene or Protein evidence | It was found that PIN inhibited the proliferation of p53 wild type colon and prostate tumor cells (HCT116 and LNCaP) while in breast cells the inhibition of growth was observed only in p53 mutant cells (MDA-MB-231). | |
| Target pathways | NA | |
| IC50 | DPPH and Hydroxyl Radical Scavenging Activities 34.7 ± 5.0 μg/mL and 1.8 ± 0.20 μg/mL respectively. | |
| Potency | Pinoresinol showed cytotoxic, anti-proliferative and pro-oxidant activity in human breast tumour cells, independent of their oestrogen receptor status. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, HCT116, LNCaP | |
| Additional information | Pinoresinol inhibits proliferation and induces differentiation on human HL60 leukemia cells. | |
| PubChem ID | 73399 | |
| Additional PMIDs | 26246833 18647433 21943063 27604292 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:666941-1 | |
| Safety | NA |