| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1995 | |
| Phytochemical name or plant extracts | (+)-baphicacanthcusines A | |
| PMID | 32501005 | |
| Literature evidence | Four pairs of stereoisomeric indole alkaloids, (±)-baphicacanthcusines A-D (1-4), and one new indole alkaloid, baphicacanthcusine E (5), together with nine known compounds were identified from the leaves of Baphicacanthus cusia. (±)-1 and -2 possess an unprecedented skeleton in which two indole moieties are bridged by a phenylpropane unit. (±)-3 represents the first natural dispiro-oxazolidinone bisoxindoles. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Baphicacanthus cusia | |
| Geographical availability | Assam, Bangladesh, China South-Central, China Southeast, East Himalaya, Hainan, Laos, Myanmar, Taiwan, Thailand, Tibet, Vietnam | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 32.2 ± 1.1 μM against MCF-7 | |
| Potency | Compounds (±)-1, (-)-2, and 11 exhibited cytotoxicity against MCF-7 cells with IC50 values of 20.0-78.5 μM. Compound 1 is baphicacanthcusines A. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Compounds (+)-1 and 11 also displayed cytotoxicity against HCT-116 cells with IC50 values of 78.0 ± 2.4 and 27.1 ± 1.9 μM, respectively. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:45829-1 | |
| Safety | NA |