| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-555 | |
| Phytochemical name or plant extracts | (+)-Dihydrokaempferol | |
| PMID | 31370334 | |
| Literature evidence | The in vitro antityrosinase, antioxidant, and cytotoxic activities of the isolated compounds (1-8) were evaluated. (+)-Dihydrokaempferol (4) exhibited higher monophenolase inhibitory activity than both kojic acid and α-arbutin. | |
| IUPAC name | (2R,3R)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Manilkara zapota. | |
| Geographical availability | Belize, Colombia, Costa Rica, El Salvador, Guatemala, Honduras, Mexico Central, Mexico Gulf, Mexico Northeast, Mexico Northwest, Mexico Southeast, Mexico Southwest, Nicaragua, Panamá | |
| Plant parts | Bark | |
| Other cancers | Breast cancer, Lung cancer, Liver cancer, Stomach cancer, Colon cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | (+)-dihydrokaempferol (4) also demonstrated potent cytotoxicity in breast carcinoma cell line (BT474), lung bronchus carcinoma cell line (Chago-K1), liver carcinoma cell line (HepG2), gastric carcinoma cell line (KATO-III), and colon carcinoma cell line (SW620). | |
| Cell line/ mice model | BT-474, Chago-K1, HepG2, KATO-III, SW620 | |
| Additional information | NA | |
| PubChem ID | 122850 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:152641-2 | |
| Safety | NA |