| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1856 | |
| Phytochemical name or plant extracts | (+)- altholactone | |
| PMID | 25865074 | |
| Literature evidence | Compounds 4 and 10 showed strong activity against all three human cancer cell lines with IC50 values in the range of 0.538 to 4.25 μg/ml, while compounds 2, 4, 10 and 14 showed potent cytotoxicity against NCI-H187 with IC50 values in the range of 0.072 to 2.17 μg/ml. | |
| IUPAC name | (2R,3R,3aS,7aS)-3-hydroxy-2-phenyl-2,3,3a,7a-tetrahydrofuro[3,2-b]pyran-5-one | |
| Phytochemicals’ class or type of plant extracts | Styryllactones | |
| Source of phytochemicals or plant Extracts | Goniothalamus elegants Ast | |
| Geographical availability | Southeast Asia | |
| Plant parts | Bark | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | KB, MCF-7 and NCI-H187 | |
| Additional information | Altholactone treatment also results in down-regulation of STAT3 target genes such as survivin, and Bcl-2 followed by up regulation of pro-apoptotic Bax protein. | |
| PubChem ID | 442513 | |
| Additional PMIDs | 28178219 | |
| Additional sources of information | NA | |
| Safety | NA |