| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1151 | |
| Phytochemical name or plant extracts | Pennogenin 3-O-α-L-rhamnopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside | |
| PMID | 24991111 | |
| Literature evidence | Pennogenyl saponins 5 and 6 exhibited cytotoxic activity against HL-60, HeLa and MCF-7 tumour cells with IC50 values of 1.0 ± 0.04 μg/ml, 1.8 ± 0.072 μg/ml and 2.4 ± 0.096 μg/ml respectively, and 2.0 ± 0.08 μg/ml, 2.5 ± 0.125 μg/ml and 3.2 ± 0.128 μg/ml respectively. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Pennogenyl saponin | |
| Source of phytochemicals or plant Extracts | Paris quadrifolia | |
| Geographical availability | Altay, Austria, Baltic States, Belarus, Belgium, Bulgaria, Buryatiya, Central European Rus, Chita, Corse, Czechoslovakia, Denmark, East European Russia, Finland, France, Germany, Great Britain, Greece, Hungary, Iceland, Inner Mongolia, Irkutsk, Italy, Kazakhstan, Krasnoyarsk, Manchuria, Mongolia, Netherlands, North Caucasus, North European Russi, Northwest European R, Norway, Poland, Romania, Sardegna, South European Russi, Spain, Sweden, Switzerland, Transcaucasus, Turkey, Tuva, Ukraine, West Siberia, Xinjiang, Yakutskiya, Yugoslavia | |
| Plant parts | Rhizome | |
| Other cancers | Breast cancer, Cervical cancer, Leukemia | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 2.4 ± 0.096 μg/ml against MCF-7 | |
| Potency | Pennogenyl saponins 5 and 6 exhibited cytotoxic activity against HL-60, HeLa and MCF-7 tumour cells with IC50 values of 1.0 ± 0.04 μg/ml, 1.8 ± 0.072 μg/ml and 2.4 ± 0.096 μg/ml respectively, and 2.0 ± 0.08 μg/ml, 2.5 ± 0.125 μg/ml and 3.2 ± 0.128 μg/ml respectively. | |
| Cell line/ mice model | HL-60, HeLa and MCF-7 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:539724-1 | |
| Safety | NA |