| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-168 | |
| Phytochemical name or plant extracts | 7β-(3-Ethyl-cis-crotonoyloxy)-1α-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone (ECN) | |
| PMID | 31337063 | |
| Literature evidence | Therefore, research on searching for promising compounds with metabolism that suppress phosphorylation or transcription of STAT3 in TNBC cells is important. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Sesquiterpene | |
| Source of phytochemicals or plant Extracts | Tussilago farfara | |
| Geographical availability | Afghanistan, Albania, Algeria, Altay, Austria, Baltic States, Belarus, Belgium, Bulgaria, Buryatiya, Central European Rus, China North-Central, China South-Central, China Southeast, Corse, Cyprus, Czechoslovakia, Denmark, East Aegean Is., East European Russia, East Himalaya, Egypt, Finland, France, Føroyar, Germany, Great Britain, Greece, Hainan, Hungary, Iceland, Inner Mongolia, Iran, Ireland, Irkutsk, Italy, Kazakhstan, Kirgizstan, Krasnoyarsk, Kriti, Krym, Lebanon-Syria, Libya, Manchuria, Morocco, Nepal, Netherlands, North Caucasus, North European Russi, Northwest European R, Norway, Pakistan, Poland, Qinghai, Romania, Sardegna, Sicilia, South European Russi, Spain, Sweden, Switzerland, Tadzhikistan, Tibet, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Turkmenistan, Ukraine, Uzbekistan, West Himalaya, West Siberia, Western Sahara, Xinjiang, Yakutskiya, Yugoslavia | |
| Plant parts | Flowers | |
| Other cancers | Breast cancer | |
| Target gene or protein | STAT-3 | |
| Gene or Protein evidence | ECN inhibited JAK-STAT3 signaling and suppressed the expression of STAT3 target genes. | |
| Target pathways | JAK-STAT3 signaling | |
| IC50 | NA | |
| Potency | Therefore, ECN can be an effective chemotherapeutic agent for breast cancer treatment. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | Here, 7β-(3-Ethyl-cis-crotonoyloxy)-1α-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone (ECN), a compound isolated from Farfarae Flos showed a potent cytotoxic effect on MDA-MB-231 cells. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:256904-1 | |
| Safety | NA |