Phytochemical Name : (3aR,4aS,5S,7aS,8S,9aR)-5-hydroxy-4a,8-dimethyl-3-methylen-decahydroazuleno[6,5-b]furan-2(3H)-on
| Properties |
Information |
| PhytoCAT-ID |
PhytoCAT-1476 |
| Phytochemical name or plant extracts |
(3aR,4aS,5S,7aS,8S,9aR)-5-hydroxy-4a,8-dimethyl-3-methylen-decahydroazuleno[6,5-b]furan-2(3H)-on |
| PMID |
29621599 |
| Literature evidence |
All isolated compounds (1-14) were tested in vitro for their cytotoxic activities against the MDA-MB-231, HGC-27 cancer cell lines, of which compounds 1-3, 6, 7, 11 and 12 showed significant cytotoxic activities with IC50 values ranging from 2.67 to 12.34 μM. |
| IUPAC name |
(3aR,4aS,5S,7aS,8S,9aR)-5-hydroxy-4a,8-dimethyl-3-methylen-decahydroazuleno[6,5-b]furan-2(3H)-on |
| Phytochemicals’ class or type of plant extracts |
Sesquiterpene lactones |
| Source of phytochemicals or plant Extracts |
Carpesium abrotanoides |
|
| Geographical availability |
Afghanistan, Albania, Altay, Austria, Belgium, Bulgaria, China North-Central, China South-Central, China Southeast, Czechoslovakia, East Himalaya, Georgia, Germany, Greece, Hainan, Hungary, Iran, Iraq, Italy, Japan, Kazakhstan, Korea, Nepal, Netherlands, North Caucasus, Pakistan, Poland, Romania, Switzerland, Taiwan, Tibet, Transcaucasus, Turkey, Turkey-in-Europe, West Himalaya, Xinjiang, Yugoslavia |
| Plant parts |
Whole plant |
| Other cancers |
Breast cancer, Stomach cancer |
| Target gene or protein |
NA |
| Gene or Protein evidence |
NA |
| Target pathways |
NA |
| IC50 |
5.32 ± 0.55 µM against MDA-MB-231 |
| Potency |
NA |
| Cell line/ mice model |
HGC-27, MDA-MB-231 |
| Additional information |
Shows significant cytotoxic activities against MDA-MB-231, HGC-27 cells |
| PubChem ID |
NA |
| Additional PMIDs |
NA |
| Additional sources of information |
https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:189330-1 |
| Safety |
NA |