| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-78 | |
| Phytochemical name or plant extracts | (1α,2α,8β,9β)-1,8-bis(acetyloxy)-2,9-bis(benzoyloxy)-14-hydroxy-β-dihydroagarofuran | |
| PMID | 23810286 | |
| Literature evidence | It was assessed for its antiproliferative activity, and it suppressed the viability of MCF-7 breast cancer cells with an IC50 of 17±1μM. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Sesquiterpene | |
| Source of phytochemicals or plant Extracts | Celastrus paniculatus | |
| Geographical availability | Andaman Is., Assam, Bangladesh, Cambodia, China South-Central, China Southeast, Christmas I., East Himalaya, Hainan, India, Jawa, Laos, Lesser Sunda Is., Malaya, Myanmar, Nepal, Philippines, Sri Lanka, Sulawesi, Sumatera, Taiwan, Thailand, Vietnam, West Himalaya | |
| Plant parts | Whole plants | |
| Other cancers | Breast cancer | |
| Target gene or protein | AKT, NF-κB, p53, MAPK | |
| Gene or Protein evidence | Western blot analysis established its ability to target a broad range of signaling effectors related to survival and cell cycle progression, including Akt, NF-κB, p53, and MAP kinases. | |
| Target pathways | NA | |
| IC50 | 17±1 μM against MCF-7 | |
| Potency | It was assessed for its antiproliferative activity, and it suppressed the viability of MCF-7 breast cancer cells with an IC50 of 17±1μM. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | In addition, flow cytometry analysis indicates increased reactive oxygen species production in response to this compound. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:160439-1 | |
| Safety | NA |